A case study of reading education for middle school students with learning disabilities

The purpose of this study was to investigate The Achieve Reading Curriculum, a reading curriculum based on whole language principles designed for middle school students with learning disabilities. A qualitative intrinsic case study was conducted using four sixth grade middle school students with learning disabilities as participants. Ethnographic methodology was used to focus on the multifaceted structure of classroom life and to acquire a thorough understanding of the connections between participants and teacher. A teacher as researcher approach facilitated insights on a daily basis due to the interaction between participants and teacher. Data collection procedures included observations/field notes, teacher journal, student interviews, parent interviews, and student written work. Categories were generated through the constant comparison method with continual refining and analysis. The participants\u27 reading ability developed as a result of the Achieve Reading Curriculum. Data indicated the participants demonstrated their developing reading ability through increasing levels of class involvement, class discussions, novel study, teacher interview results, writing activities, and time on task/reading attending behaviors. The motivation of the participants to read increased due to components of the Achieve Reading Curriculum, an increase in class participation and discussion, and stronger writing and creativity efforts produced by the participants as the study progressed. Parental support was critical to the effective implementation of the program and the success of the participants. The perceptions parents had of the program and its results, the reading encouragement offered by the parents to the participants and the teacher appreciation were demonstrative of their support. Data triangulated from parent interviews, student interviews, student written responses, teacher-researcher observations/fieldnotes, and teacher journal suggest the Achieve Reading Curriculum, based on whole language principles, can be effective in developing and improving the reading ability, enhancing the motivation to read, and facilitating parental support and involvement of middle school students with learning disabilities

The Disestablishment and Disendowment of the Church in Wales

The disestablishment and disendowment of the Church in Wales was a direct result of a renascent Welsh nationalism asserting itself in the daily life of Wales and in the English parliament. This thesis examines the historical, political, and social aspects of the disestablishment and disendowment of the Church

Transcriptional Regulation of VEGF-A by the Unfolded Protein Response Pathway

BACKGROUND: Angiogenesis is crucial to many physiological and pathological processes including development and cancer cell survival. Vascular endothelial growth factor-A (VEGFA) is the predominant mediator of angiogenesis in the VEGF family. During development, adverse environmental conditions like nutrient deprivation, hypoxia and increased protein secretion occur. IRE1alpha, PERK, and ATF6alpha, master regulators of the unfolded protein response (UPR), are activated under these conditions and are proposed to have a role in mediating angiogenesis. PRINCIPAL FINDINGS: Here we show that IRE1alpha, PERK, and ATF6alpha powerfully regulate VEGFA mRNA expression under various stress conditions. In Ire1alpha(-/-) and Perk(-/-) mouse embryonic fibroblasts and ATF6alpha-knockdown HepG2 cells, induction of VEGFA mRNA by endoplasmic reticulum stress is attenuated as compared to control cells. Embryonic lethality of Ire1alpha-/- mice is due to the lack of VEGFA induction in labyrinthine trophoblast cells of the developing placenta. Rescue of IRE1alpha and PERK in Ire1alpha(-/-) and Perk(-/-) cells respectively, prevents VEGFA mRNA attenuation. We further report that the induction of VEGFA by IRE1alpha, PERK and ATF6 involves activation of transcription factors, spliced-XBP-1, ATF4 and cleaved ATF6 respectively. CONCLUSIONS/SIGNIFICANCE: Our results reveal that the IRE1alpha-XBP-1, PERK-ATF4, and ATF6alpha pathways constitute novel upstream regulatory pathways of angiogenesis by modulating VEGF transcription. Activation of these pathways helps the rapidly growing cells to obtain sufficient nutrients and growth factors for their survival under the prevailing hostile environmental conditions. These results establish an important role of the UPR in angiogenesis

Self-tuning experience weighted attraction learning in games

Self-tuning experience weighted attraction (EWA) is a one-parameter theory of learning in games. It addresses a criticism that an earlier model (EWA) has too many parameters, by fixing some parameters at plausible values and replacing others with functions of experience so that they no longer need to be estimated. Consequently, it is econometrically simpler than the popular weighted fictitious play and reinforcement learning models. The functions of experience which replace free parameters “self-tune” over time, adjusting in a way that selects a sensible learning rule to capture subjects’ choice dynamics. For instance, the self-tuning EWA model can turn from a weighted fictitious play into an averaging reinforcement learning as subjects equilibrate and learn to ignore inferior foregone payoffs. The theory was tested on seven different games, and compared to the earlier parametric EWA model and a one-parameter stochastic equilibrium theory (QRE). Self-tuning EWA does as well as EWA in predicting behavior in new games, even though it has fewer parameters, and fits reliably better than the QRE equilibrium benchmark

Fish larval nutrition and feed formulation: knowledge gaps and bottlenecks for advances in larval rearing

Despite considerable progress in recent years, many questions regarding fish larval nutrition remain largely unanswered, and several research avenues remain open. A holistic understanding of the supply line of nutrients is important for developing diets for use in larval culture and for the adaptation of rearing conditions that meet the larval requirements for the optimal presentation of food organisms and/or microdiets. The aim of the present review is to revise the state of the art and to pinpoint the gaps in knowledge regarding larval nutritional requirements, the nutritional value of live feeds and challenges and opportunities in the development of formulated larval diets.Norwegian Ministry of Fisheries; Research Council of Norway [CODE-199482, GutFeeling-190019]; Spanish Ministry of Science and Innovation MICINN + FEDER/ERDF [AGL2007-64450-C02-01, CSD2007-0002]; project HYDRAA [PTDC/MAR/71685/2006]; Fundacao para a Ciencia e a Tecnologia (FCT), Portugal; FEDER; EC [LIFECYCLE- 222719]; EU RTD [FA0801]info:eu-repo/semantics/publishedVersio

The Impact of Quantitative Easing on UK Bank Lending: Why Banks Do Not Lend to Businesses?

The growing proportion of UK bank lending to the financial sector reached a peak in 2007 just before the onset of the Global Financial Crisis (GFC). This marks a trend in the dwindling amount of bank lending to private sector non-financial corporations (PNFCs), which was exacerbated with the Great Recession. Many central banks aimed to revive bank lending with quantitative easing (QE) and unconventional monetary policy. We propose an agent based computational economics (ACE) model which combines the main factors in the economic environment of QE and Basel regulatory framework to analyse why UK banks do not prioritize lending to non-financial businesses. The lower bond yields caused by QE encourage big firms to substitute away from bank borrowing to bond issuance. In addition, the risk weight regime of Basel I/II on capital induces banks to favour mortgages over business loans to small and medium enterprises (SMEs). The combination of lower bond yields and Basel II/III capital requirements on banks, which, respectively, impact demand and supply of credit in the UK, plays a role in the drop of bank loans to businesses. The ACE model aims to reinstate policy regimes that form constraints and incentives for the behaviour of market participants to provide the causal factors in observed macro-economic phenomena

Reassessing the protean career concept: Empirical findings, conceptual components, and measurement

This article was published in the serial Journal of Organizational Behavior [© John Wiley & Sons, Ltd.] The definitive version is available at: http://dx.doi.org/10.1002/job.1908The protean career concept is a widely acknowledged contemporary career model, but conceptual and empirical analysis of the model is scarce. We provide an integrative literature review of empirical research and note that the research is hampered by inconsistent use of terminology and methodological limitations. First, we show that the two protean metacompetencies-adaptability and identity-have been relatively neglected as the research has evolved. Second, we describe how preexisting protean measures are limited in covering the full range of the concept. Finally, we draw on career theory to suggest four conceptual components as a basis for future model development and offer suggestions for research that tests the utility of the protean career concept in relation to other similar constructs. © 2013 John Wiley & Sons, Ltd